ARI Publication 40 – 2013 Version ARI Survey of Parent Ratings of Treatment Efficacy: % Worse % No Change % Better Number of Reports Digestive Enzymes 3% 35% 62%

ARI Publication 40 – 2013 Version For more info, see the review by Rossignol and Frye, Melatonin in autism spectrum disorders: a systematic review and meta-analysis. Dev Med Child Neural

ARI Publication 40 – 2013 Version Melatonin Rationale: Many children and adults with autism have sleep problems, including falling asleep,nighttime waking, and early waking. These sleep problems have a strong

AR Publication 40 – 2013 Version PARENT RATINGS OF BEHAVIORAL EFFECTS OF BIOMEDICAL INTERVENTIONS Autism Research Institute • 4182 Adams Avenue • San Diego, CA 92116The parents of autistic children

ARI Publication 40 – 2013 Version Summary Autism is a very complex disorder, and  involves many genetic and environmental factorsthat are not well-understood. However, there are many biomedical abnormalities that

ARI Publication 40 – 2013 Version Ito H etal, Rndingsofbrain 99mTc-EGJSPECTin high-li.Jnctioningautism-3-dimensionalstereotadicROItemplateanalysisofbrain SPECT. J MedInvest. 2005Feb;52(1-2):49-56. (15d7i/clren with autism, 5 d7ilclren withepilepsy)Gupta SK, Ratnam BV. Cerebralperfusion abnormalities in children with

ARI Publication 40 – 2013 Version CGI, ABC, and ATEC scales, but the differences between treatment and placebo groups were notstatistically significant. Rossignol DA, et al: Hyperbaric treatment for children

ARI Publication 40 – 2013 Version Research on Treatment: There are several open-label studies of HBOT therapy for children, and most suggest that HBOTtherapy might be helpful, but one open-label

ARI Publication 40 – 2013 Version Hyperbaric Oxygen Therapy (HBOT) Rationale: There is substantial evidence of decreased blood flow in brains of most children withautism, suggesting a need for more

ARI Publication 40 – 2013 Version ACTOS: ACTOS (pioglitazone) has multiple effects, including the ability to decrease inflammation.An open study of ACTOS in 25 children with autism for 3-4 months found